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T8536 |
Filastatin
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Antifungal
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Filastatin is a long-lasting inhibitor of Candida albicans filamentation, and has potent antifungal effect. |
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T22387 |
NSC 55655
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5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione |
Others
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NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) possesses antimicrobial and antioxidant activities and inhibits the proliferation of B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi , A. niger and C... |
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T2305 |
Isavuconazole
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BAL-4815,RO-0094815 |
P450
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Antibiotic
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Antifungal
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Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabr... |
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T4040 |
AN2718
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Antifungal
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AN2718 inhibits protein synthesis through the OBORT mechanism and displays broad antifungal effectiveness. |
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T71939 |
PS77
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PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2. |
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T35700 |
FR901379
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FR901379 is an echinocandin-like antifungal lipopeptide.1 It is active against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR901379 is protective against... |
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T36434 |
Sordarin sodium
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Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mi... |
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T63802 |
Antifungal agent 35
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Antifungal agent 35 is an effective antifungal agent that potentiates the antifungal activity of fluconazole against C. albicans. |
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T80293 |
RP-1
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RP-1, an antimicrobial peptide, exhibits activity against a range of pathogens, including S. aureus, S. typhimurium, E. coli, and C. albicans [1]. |
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T76264 |
Nisin Z
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Nisin Z, an antimicrobial and anti-inflammatory peptide, demonstrates efficacy against Gram-positive bacteria and fungi, including C. albicans [1] [4]. |
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T36533 |
SCH 725674
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SCH 725674 is an antifungal macrolide originally isolated from Aspergillus. It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively). |
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T74272 |
Antifungal agent 84
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Antibacterial Agent 84, an antifungal compound, effectively inhibits candidiasis through a CNB1-dependent mechanism and reduces the viability of the C. albicans biofilm [1]. |
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T80629 |
2-Dodecanol
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2-Dodecanol suppresses both hyphal development and SIR2 gene expression in Candida albicans [1]. |
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T36054 |
D13
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D13 is an acylhydrazone antifungal.1 It is active against C. neoformans in vitro (MIC80 = 0.06 μg/ml). D13 (20 mg/kg per day, p.o.) increases survival in mouse models of C. neoformans, C. albicans, or A. fumigatus infect... |
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T83715 |
Histatin 3 TFA
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Hst-3 |
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Histatin 3, a salivary antimicrobial peptide, exhibits activity against C. albicans with an LC50 of 9.2 µM. Additionally, at a concentration of 12 µM, it promotes actin polymerization in cell-free assays. |
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T80407 |
Peptide 5g
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Peptide 5g, an antimicrobial peptide, inhibits E. coli, S. aureus, and C. albicans, exhibiting minimum inhibitory concentration (MIC) values of 30, 10, and 12.5 μg/mL, respectively [1]. |
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T74273 |
Antifungal agent 52
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Antifungal agent 52 (compound 6c), a tetrazole derivative, inhibits ergosterol synthesis and significantly exhibits antifungal activity against Candida albicans by affecting the permeabilization of the C. albicans sessil... |
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T36437 |
Sphinganine (d17:0)
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Sphinganine (d17:0) |
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Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as a... |
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T61308 |
Antifungal agent 27
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Antifungal agent 27 (compound 7) is a chemical compound possessing antifungal properties. It exhibits moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibit... |
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T80365 |
Maximin H39
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Maximin H39, an antimicrobial peptide, exhibits antibacterial activity against C. albicans, S. aureus, and B. subtilis with minimum inhibitory concentrations (MIC) of 9.4, 9.4, and 18.8 μg/mL, respectively. It also demon... |
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T80400 |
Peptide 5e
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Peptide 5e, an antimicrobial peptide, exhibits inhibitory activity against E. coli, S. aureus, and C. albicans with respective minimum inhibitory concentration (MIC) values of 30, 5, and 25 μg/mL [1]. |
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T37730 |
Saccharocarcin A
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Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhib... |
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T80369 |
Maximin 68
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Maximin 68, an antimicrobial peptide, exhibits antibacterial activity against C. albicans, S. aureus, E. coli, and B. subtilis, with MIC values of 18.8, 9.4, 37.5, and 9.4 μg/mL, respectively. It also possesses hemolytic... |
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T83689 |
Histatin 8 TFA
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Hst-8 |
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Histatin 8, a salivary antimicrobial peptide derived from proteolytic fragments of histatin 3 and histatin 5, exhibits activity against A. baumannii strains, both colistin-susceptible and -resistant, at a concentration o... |
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T63077 |
Chitin synthase inhibitor 12
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Chitin synthase inhibitor 12, a Chitin synthase (CHS) inhibitor, showed excellent CHS inhibition (IC50: 0.16 mM). Chitin synthase inhibitor 12 is also a broad-spectrum antifungal agent resistant to resistant fungal varia... |
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T83699 |
LL-37 (18-37) (human) TFA
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KR-20,hCAP-18,CAP-18,Cathelicidin,FALL-39 |
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LL-37 (18-37), an antimicrobial peptide fragment of LL-37, exhibits activity against S. aureus and C. albicans, with minimum lethal concentrations of 4 µM and 10 µM, respectively. Additionally, it inhibits E. histolytica... |
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T74956 |
Chitin synthase inhibitor 10
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Chitin Synthase Inhibitor 10, as a potent chitin synthase inhibitor, exhibits remarkable inhibitory activity with an IC50 of 0.11 mM. It also functions as an antifungal agent, demonstrating substantial effectiveness agai... |
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T80340 |
ROAD-1
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ROAD-1, a Rhesus Macaque oral mucosal α-defensin, exhibits antimicrobial activity against S. aureus, E. coli, and C. albicans [1]. |
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T38044 |
Reveromycin B
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Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against... |
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T80367 |
Maximin 78
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Maximin 78 is an antimicrobial peptide with antibacterial activity against C. albicans, S. aureus, and B. subtilis, exhibiting minimum inhibitory concentrations (MIC) of 37.5, 4.7, and 37.5 μg/mL, respectively. Additiona... |
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T37423 |
Reveromycin D
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Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μ... |
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T60965 |
Anticandidal agent-1
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Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent that inhibits biofilm through blocking hyphal elongation and filamentation. Anticandidal agent-1 exhibits anticandidal activity against... |
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T36336 |
Burnettramic Acid A
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Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.... |
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T80362 |
Human α-Defensin 6
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Human α-Defensin 6, a 32-residue, cysteine-rich peptide, plays a crucial role in mucosal immunity by inhibiting bacterial invasion. It achieves this through the formation of ordered self-assembly fibrils and nanonets, wh... |
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T35423 |
7-oxo Staurosporine
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7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respe... |
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T37749 |
Benanomicin A
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Benanomicin A is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. a... |
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T37750 |
Benanomicin B (formate)
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Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. a... |
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T79467 |
Antifungal agent 60
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Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates ... |
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T71761 |
Carbazomycin B
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Carbazomycin B is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against a panel of seven fungi
and a panel of seven bacteria, as well as P. falciparum a... |
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T83849 |
OP-145 TFA
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acetyl-IGKEFKRIVERIKRFLRELVRPLR-amide,P60.4-Ac |
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OP-145, a derivative of the antimicrobial peptide LL-37, is a synthetic antimicrobial peptide showing activity against E. coli, P. aeruginosa, C. albicans, and A. niger, with minimum inhibitory concentrations (MICs) of 2... |
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T35742 |
IKD-8344
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IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y... |
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T80345 |
Bovine tracheal antimicrobial peptide
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Bovine tracheal antimicrobial peptide, derived from the tracheal mucosa, exhibits antimicrobial efficacy against E. coli D31, K. pneumoniae 13883, S. aureus 25923, P. aeruginosa 27853, and C. albicans 14053, with respect... |
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T35772 |
Emestrin
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Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacter... |
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T35671 |
Salazinic Acid
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Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30... |
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T36057 |
Diallyl Tetrasulfide
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ICD-1585 |
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Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active again... |
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T37963 |
Methylchloroisothiazolinone/Methylisothiazolinone Mixture
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Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002,... |
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T83706 |
BMAP 28 (bovine) TFA
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Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28 |
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Bovine Myeloid Antimicrobial Peptide (BMAP) 28, a synthetic peptide derived from bovine cathelicidin-5 (amino acids 132-158), exhibits antimicrobial activity against E. coli, S. aureus, MRSA, S. epidermidis, and the fung... |
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T69995 |
Chlorhexidine-d8 HCl
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Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth ... |
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T35452 |
β-Defensin-3 (human) (trifluoroacetate salt)
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β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and ... |
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T35453 |
β-Defensin-4 (human) (trifluoroacetate salt)
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β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at... |
